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doi: 10.1038/s41392-022-01188-4

Protocol duration: Typically 412 weeks , depending on study design and tracking goals

40 In patients with T2DM, the SURPASS-2 trial compared tirzepatide with semaglutide 1 mg (both as add-on therapies to metformin) and found tirzepatide was either noninferior or superior at all doses (5 mg, 10 mg 15 mg), for both HbA 1c reduction and weight loss at 40 weeks